The whole family is nasopharyngeal cancer？

Volume 7, Issue 3, June 2022     |     PP. 192-200      |     PDF (159 K)    |     Pub. Date: May 18, 2022
DOI: 10.54647/cm32747    75 Downloads     4227 Views  

Author(s)

Dali Feng, Cancer prevention and treatment center/The Second People’s Hospital of Three Gorges University/The Second People’s Hospital of YiChang,Yichang, Hubei 443000, China
Wenliang Zhu, Department of Minimally Invasive & Interventional Radiology, Sun Yat-sen University Cancer Center;  State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China. ADD: 651 Dongfeng Road, East, Guangzhou, China
Tingting Zhang, Clinical Laboratory/The Second People’s Hospital of Three Gorges University/The Second People’s Hospital of YiChang,Yichang,Hubei 443000, China
Youkun Liu, Clinical Laboratory/The Second People’s Hospital of Three Gorges University/The Second People’s Hospital of YiChang,Yichang,Hubei 443000, China

Abstract
Background Nasopharyngeal carcinoma (NPC) is particularly prevalent in the southern provinces of China,the aetiology of NPC is multifactorial but not clear.NPC case reports have a long history and many NPC cases of familial aggregation reported,but no report about NPC in parents and children in one family.
Case Presentation We report a rare case of familial aggregation of NPC, according to the order of incidence,this paper collected 5 cases of NPC in one family:father,mather Sons and daughters;to explore their diagnosis,treatment process and follow-up to understand the prognosis of the disease.
Conclusion From this case we can explore the most possible causes and possible measures for the family aggregation of NPC.

Keywords
nasopharyngeal cancer;familial aggregation;follow up

Cite this paper
Dali Feng, Wenliang Zhu, Tingting Zhang, Youkun Liu, The whole family is nasopharyngeal cancer？ , SCIREA Journal of Clinical Medicine. Volume 7, Issue 3, June 2022 | PP. 192-200. 10.54647/cm32747

References

[ 1 ] Chen YP,Chan ATC,Le QT,etal.Nasopharyngeal carcinoma[J].Lancet.2019 Jul 6;394(10192):64-80.
[ 2 ] Wei KR,Zheng RS,Zhang SW,etal.Nasopharyngeal carcinoma incidence and mortality in China,2013.Chin J Cancer.2017 Nov 9;36(1):90.
[ 3 ] Si Yongfeng,Tao Zhongqiang.Etiology and prevention of nasopharyngeal carcinoma [J].Otorhinolaryngology head and neck surgery,2010,17(03):163-165.
[ 4 ] Tsao SW,Yip YL,Tsang CM,et al.Etiological factors of nasopharyngeal carcinoma.Oral Oncol.2014;50(5):330-338. doi:10.1016/j.oraloncology.2014.02.006
[ 5 ] Li Weidong,Wei minerong,Lei Feng,etal.An investigation on the epidemiological risk factors of nasopharyngeal carcinoma in Zhongshan City[J].Chinese Journal of disease control,2012,16(06):486-489.
[ 6 ] Paredes-Durán LM,Del Barco-Morillo E,Baldeón-Conde MJ,etal.Familial clustering of nasopharyngeal carcinoma in non-endemic area.Report of three families[J].Acta Otorrinolaringol Esp.2017 May-Jun;68(3):164-168.
[ 7 ] Zhong Yu, Li Jing.4 cases of NPC in both husband and wife[J].Journal of practical medicine,2010,26(09):1672.
[ 8 ] Qiu Rongliang,Wu Hui,Zhang Jingwei,etal.A case report and clinical analysis of nasopharyngeal carcinoma in multiple families[J].Modern oncology,2005(04):557-558.
[ 9 ] Yu KJ,Hsu WL,Chiang CJ,et al.Cancer patterns in nasopharyngeal carcinoma multiplex families in Taiwan.Int J Cancer.2009;124(7):1622-1625.doi:10.1002/ijc.24051
[ 10 ] Paredes-Durán LM,Del Barco-Morillo E,Baldeón-Conde MJ,Medina-Valdivieso S, Guillen-Sacoto MC,Cruz-Hernández JJ.Familial clustering of nasopharyngeal carcinoma in non-endemic area. Report of three families.Carcinoma nasofaríngeo familiar en zona no endémica.Presentación de3 familias.Acta Otorrinolaringol Esp.2017;68(3):164-168. doi:10.1016/j.otorri.2016.07.006
[ 11 ] Wang chenye,Kong Limin,Yang Yuyan,etal.A survey of factors related to nasopharyngeal carcinoma in rural and urban Wenzhou[J].China public health management,2018,34(06):737-740.
[ 12 ] Zhou Rui,Zhu Jing,Zhang Tao.Application and research progress of EB virus DNA detection in nasopharyngeal carcinoma[J].Modern oncology,2019(21):3902-3905
[ 13 ] Deng Zhuoxia,Weng Jingjin,Si Yongfeng,etal.Analysis of 2-year follow-up results after primary screening in high incidence areas of NPC in Guangxi[J].Guangxi Medical Journal,2016,38(04):517-520.
[ 14 ] Simon Julia,Schroeder Lea,Ingarfield Kate,Diehl Stefan,Werner Jill,Brenner Nicole,Liu Zhiwei,Pawlita Michael,Pring Miranda,Butt Julia,Ness Andy,Waterboer Tim. Epstein-Barr virus and human papillomavirus serum antibodies define the viral status of nasopharyngeal carcinoma in a low endemic country[J].Pubmed,2020,147(2).
[ 15 ] Lu Haijie,Wang Anyu,Yang Yunli,etal.An analysis of the results of the investigation on the familial tendency of NPC[J].Journal of Guangxi Medical University,1999(02):113-114.
[ 16 ] Cheng Jiru,Cai Yonglin,Zheng Yuming,etal.Analysis of serum EB virus IgA/VCA antibody level in spouses and children of NPC patients [J].Cancer clinic of China,2009,36 (18):1037-1039.
[ 17 ] Ai Bin,Tang Jinshen,Xu Yimou,etal.Localization of pathogenic genes in nasopharyngeal carcinoma family[J].Chinese Journal of cancer clinical and rehabilitation,2014,21(12):1433-1436.
[ 18 ] Lin Shaomin.Investigation and analysis of 115 cases of NPC family tumor history [C].Hainan Cancer Association.Proceedings of the second cancer academic conference of Hainan Province.Hainan Cancer Association:Hainan Cancer Association,2005:135-136
[ 19 ] Xiong Wei.Preliminary study on genetic susceptibility and susceptibility genes of NPC [D].Central South University,2003.
[ 20 ] Li Qinglian,Luo Yan.Analysis of genetic factors in 208 cases of NPC[J].Journal of practical medicine,1995(11):724-725.
[ 21 ] Li Aidong,Tai Jun,Huang Yubei,etal.Meta analysis of the relationship between cancer family history and nasopharyngeal carcinoma in Chinese population[J].Chinese Journal of cancer control,2015,22(07):555-560.
[ 22 ] Ling Qinan,Wen Falin.Investigation report on family cancer history of 1163 patients with NPC in Sihui City[J].Cancer prevention and treatment research,1996 (04):257-258.