Trends and Effectiveness of Ajwa Dates (Phoenix dactylifera) Usage in Management of Coronary Artery Disease, Study in Urban Community of Islamabad, Pakistan.

Volume 3, Issue 1, February 2019     |     PP. 1-12      |     PDF (530 K)    |     Pub. Date: March 24, 2019
DOI:    512 Downloads     7419 Views  

Author(s)

Shagufta Zafar Qureshi, Federal Government Polyclinic Hospital, Islamabad, Pakistan
Abdul Wali Khan, Federal Government Polyclinic Hospital, Islamabad, Pakistan

Abstract
Objectives: To assess the trend and effectiveness of Ajwa dates usage in management of coronary artery disease.Methods: In this, hospital based descriptive study, 150 cases of CAD were divided into 3 groups. Group One taking Ajwa alone, group Two on allopathic medicine and group Three taking both Ajwa and allopathic treatment. Data was collected through self-constructed questionnaire. Analysis done on SPSS version 20.Results: There were 50 subjects in each group. Mean age 52 ± 12 years. M: F ratio was 2: 1. 66% of entire study population was hypertensive, 41% diabetic and 43% hyperlipidemic. Study subjects were assessed for symptoms like chest pain, dyspnea, orthopnea or mixed symptoms. 38% in group One, and 50% in group Two and Three each, had chest pain, 24%, 8% and 22% had dyspnea, 2%, 6% and 12% had orthopnea, whereas 2% 14% and 12% had mixed symptoms in each respective group. Symptomatic relief for chest pain was 37% in group One, 60% in Two and 76% in group Three (P value < 0.05). Dyspnea and orthopnea results were not statistically significant. Overall symptomatic relief was 66% in group Three (P value < 0.05), Out of 2 preparations, Ajwa paste (pulp + seed) and Ajwa combination (Ajwa paste + Ginger garlic syrup), combination therapy was better i.e. 30% in group One and 75% in group Three had symptomatic improvement. Overall, results were highly significant with P value .000. Conclusion: The study suggests that Ajwa has some role in management of CAD, especially in symptomatic improvement.

Keywords
Ajwa Dates; Coronary artery disease (CAD); Complementary and Alternate medicine (CAM); Cardiovascular Disease (CVD).

Cite this paper
Shagufta Zafar Qureshi, Abdul Wali Khan, Trends and Effectiveness of Ajwa Dates (Phoenix dactylifera) Usage in Management of Coronary Artery Disease, Study in Urban Community of Islamabad, Pakistan. , SCIREA Journal of Health. Volume 3, Issue 1, February 2019 | PP. 1-12.

References

[ 1 ] B. J. Gersh, K. Sliwa, B. M. Mayosi, S. Yusuf. Novel therapeutic concepts: the epidemic of cardiovascular disease in the developing world, global implications. European Heart Journal 2010; 31: 642–648.
[ 2 ] D. S. Celermajer, C. K. Chow, E. Marijon, N. M. Anstey, K. S. Woo. Cardiovascular disease in the developing world prevalence’s, patterns, and the potential of early disease detection.  Journal of the American College of Cardiology 2012; 60: 1207–1216. 
[ 3 ] Beaglehole R, Epping-Jordan J, Patel V, et al. Improving the prevention and management of chronic disease in low-income and middle-incomed countries: a priority for primary health care. Lancet 2008; 372: 940–99
[ 4 ] Chen C, Wei J, AlBadri A, Zarrini P, Bairey Merz CN. Coronary Microvascular Dysfunction　- Epidemiology, Pathogenesis, Prognosis, Diagnosis, Risk Factors and Therapy. Circ J. 2016; 81(1):3-11.
[ 5 ] M. Frass, R. P. Strassl, H. Friehs, M. Müllner, M. Kundi, A. D. Kaye. Use and acceptance of complementary and alternative medicine among the general population and medical personnel: a systematic review. The Ochsner Journal 2012; 12: 45–56. 
[ 6 ] P. M. Barnes, B. Bloom, R. L. Nahin. Complementary and alternative medicine use among adults and children: United States, 2007.  National Health Statistics Reports 2009; 12: 1–23.
[ 7 ] Shahadi F, Naczk M . Phenolics in Food and Nutraceuticals. CRC 2004; Press LLC.
[ 8 ] Ahmed R. Ragab, Mohamed A. Elkablawy, Basem Y. Sheik, Hany N. Baraka. Antioxidant and Tissue-Protective Studies on Ajwa Extract: Dates from Al-Madinah Al-Monwarah, Saudia Arabia. J Environ Anal Toxicol 2013; Vol 3(1): 163.
[ 9 ] Ismail Hamad, Hamada AbdElgawad, Soad Al Jaouni , Gaurav Zinta , Han Asard, Sherif Hassan et al. Metabolic Analysis of Various Date Palm Fruit (Phoenix dactylifera L.) Cultivars from Saudi Arabia to Assess Their Nutritional Quality. Molecules 2015; 20: 13620-13641.
[ 10 ] Yasin BR, El-Fawal HA, Mousa SA. Date (Phoenix dactylifera) Polyphenolics and Other Bioactive Compounds: A Traditional Islamic Remedy's Potential in Prevention of Cell Damage, Cancer Therapeutics and beyond. Int J Mol Sci. 2015;16 (12) : 30075-90.
[ 11 ] Al-Shahib W, Marshall RJ. The fruit of date palm: Its possible use as the best food for the future? Int J Food Sci Nutr 2003; 54: 247-259.
[ 12 ] Hasan NS, Amon ZH, Nor Al, et al. Nutritional composition and in vitro evaluation of the antioxidants propertiest of various dates extracts (Phoenix dactylifera L.) from Libya. Asian J Clin Nutr 2010; 2: 208-214.
[ 13 ] Saleh, E.A., Tawfik, M.S., Abu-Tarboush, H.M., 2011. Phenolic contents and antioxidant activity of various date palm (Phoenix dactylifera L.) fruits from Saudi Arabia. Food Nutr. Sci. 2, 1134– 1141.
[ 14 ] P.K. Vayalil. Date fruits (Phoenix dactylifera Linn): an emerging medicinal food. Crit. Rev. Food Sci. Nutr. 2012; 52: 249-271.
[ 15 ] D.A. Mohammed, S.Y. Al-Okbi. In-vivo evaluation of antioxidant and anti-inflammatory activity of different extracts of date fruits in adjuvant arthritis. Pol. J. Food Nutr. Sci. 2004; 13: 397-402.
[ 16 ] Zhang CR, Aldosari SA, Vidyasagar PS, Nair KM, Nair MG. Antioxidant and anti-inflammatory assays confirm bioactive compounds in Ajwa Date fruit. J Agric Food Chem. 2013; 61:5834-5840. 
[ 17 ] Enas, EA., Garg, A., Davidson, MA., Nair, VM., Huet, BA., Yusuf, S, et al. Coronary heart disease and its risk factors in first-generation immigrant Asian Indians to the United States of America. Indian Heart Journal, 1996; 48: 343–353.
[ 18 ] Milan Gupta, Anand V. Doobay, Narendra Singh, Sonia S. Anand, Faisal Raja, Fazeelat Mawji, et al. Risk factors, hospital management and outcomes after acute myocardial infarction in South Asian Canadians and matched control subjects. CMAJ 2002; 166(6): 717–722.
[ 19 ] Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, McQueen M, Budaj A, Pais P, Varigos J, Lisheng L; INTERHEART Study Investigators. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet 2004; 364 (9438) : 937-52.
[ 20 ] Houston, M. The role of magnesium in hypertension and cardiovascular disease. J Clin Hypertens (Greenwich), 2011; 13: pp. 843-47.
[ 21 ] Laurant, P., Touyz, R.M. Physiological and pathophysiological role of magnesium in the cardiovascular system: implications in hypertension. Journal of Hypertension, 2000; 18: 1177–1191.
[ 22 ] Borochov-Neori, H., Judeinstein, S., Greenberg, A., Volkova, N., Rosenblat, M., Aviram, M. Antioxidant and Antiatherogenic Properties of Phenolic Acid and Flavonol Fractions of Fruits of ‘Amari’ and ‘Hallawi’ Date (Phoenix dactylifera L.) Varieties. J Agric Food Chem 2015; 63: 3189-95.
[ 23 ] R. C. Arora, S. Arora, and R. K. Gupta, “The long-term use of garlic in ischemic heart disease. An appraisal,” Atherosclerosis 1981; 40: 175–179.
[ 24 ] Y. S. K. Khoo, Z. Aziz. Garlic supplementation and serum cholesterol: a meta-analysis. Journal of Clinical Pharmacy and Therapeutics 2009; 34: 133–145.